Comparison of self nano emulsifying drug versus conventional drug in oral lesions and potentially malignant disorders
Sanjeev Laller, PDM Dental College and Research Institute, India
Title: Comparison of self nano emulsifying drug versus conventional drug in oral lesions and potentially malignant disorders
Biography
Abstract
Introduction: Nanotechnology has revolutionized each and every sector including medical industry. Nanotechnology is an
emerging technology that has shown great potential for delivering bioactive compounds in the functional foods to improve
human health. Curcumin/turmeric has various health-beneficial properties in numerous studies. However its bioavailability
is low due to its limited intestinal uptake and rapid metabolism. The aim of our research study was to compare novel selfnano
emulsifying curcumin formulations with improved oral bioavailability and thus its beneficial effects; with conventional
curcumin formulations in oral lesions and potentially malignant disorders.
Materials & Methodology: 100 (50 in Group-A and 50 in Group-B) subjects diagnosed clinically with oral lesions and oral
potentially malignant disorders were included in this study. The Group-A patients were administered commercially available
nano-turmeric systemically and topically and Group-B was given systemic and topical application of normal or conventional
turmeric. The clinical appearance of lesions (based on the Thongprasom score) and pain severity (based on the visual analogue
score) were recorded before treatment and at the end of the first, second and fourth week of the intervention.
Results: Using repeated measures analyses of variance, there were statistically significant differences observed between both the
groups in pain intensity and clinical appearance of oral lesions (more positive results in patients treated with nano curcumin
formulations).
Conclusion & Significance: Curcumin nano formulations can bring about significant clinical improvements in oral lesions
and potentially malignant disorders. Using a nanomicell formulation of oral curcumin could be considered as an alternative
treatment for such patients as this drug is safe and has few side effects. However, it needs further studies with larger sample
sizes and longer follow-up periods.